Trimethylsilyl esters and solvates chelates acid quinolin-3-carboxylic. Preparation and application process of quinolones.

摘要

Trimethylsilyl esters and solvates chelates ACIDS quinoline-3-carboxylic acids. PREPARATION AND APPLICATION PROCESS quinolones. NEW PRODUCTS DESCRIBED IA and IB; Wherein X, X1 and X2 REPRESENT INTERCHANGEABLY hydrogen, halogen, amino or methyl; R alkyl, cycloalkyl, aryl; X2R can form a heterocycle; R1 halogen or acyloxy; M boron or aluminum, N a value of 0.5 to 2.0, and (A) an amino. * FIG * Silylation of II (A = X1) with hexamethyldisilazane, IA WHICH RENDER is combined with BORON (M) wrapper to form the solvate IB. By replacing X1 by an amine (A) and subsequent hydrolysis, adjusting pH 6, 0-7, 2, it quinolone II. The compounds IA and IB ARE INTERESTING IN quinolone PROCESS APPLICATION IN MEDICINE PRODUCT human and animal.