Pertussis toxin mutants, Bordetella strains capable of producing such mutants and their use in the development of vaccines antipertussicas.

摘要

These mutants (PT) ARE immunologically active, having reduced or no toxicity, and are characterized in that at least one of the amino acid residues Glu129, ASP11, TRP26, Arg 9, Fe50, ASP1, Arg13, TYR130, GLY86, LLE88, TIR44, THR53 and Gly80 subunit amino acid is deleted and replaced by a residue different amino acid. Bordetella CHAINS AND SEPARATE capable of providing such mutant PT and meaning and methods for obtaining them are also described. STRINGS AND Bordetella mutants produced are particularly suitable for the preparation of vaccines CELLULAR AND VACCINE PERTUSSIS acellular.