RAR.BETA. SELECTIVE RETINOID COMPOUNDS FOR INHIBITING GENE EXPRESSION PROMOTED BY AP1 PROTEIN AND THEIR USE IN THERAPY

摘要

Retinoid compounds which repress expression of the gene promoted by AP1protein but which do not significantly activate expression of the genes havingRA-responsive elements in their promoter region through RAR.alpha. andRAR.GAMMA. receptor subtypes, are used, with reduced side effects, fortreating diseases and conditions which are responsive to therapy withretinoids.