Synthesis of 17beta -cyano-3-ethoxy-17alpha-hydroxy-6-methylandrosta-3,5, 9(11)-triene

摘要

17 beta -Cyano-3,17 alpha -dihydroxy-6-methylandrosta-3,5,9(11)-triene 3-ethyl ether (II) is prepared by reacting 3-hydroxy-6-methylandrosta-3,5,9(11)-trien-17-one 3- ethyl ether (I) with hydrogen cyanide at a pH of about 7 to about 11. The product is a useful intermediate in the production of pharmacologically active steroids including methylprednisolone.