Method of culturing m. bovis in low available iron media and production of infectious bovine keratoconjunctivitis vaccine therefrom

摘要

An improved vaccine against infectious bovine keratoconjunctivitis is provided which is derived from an appropriate Moraxella bovis strain cultured in a relatively low available iron medium which induces the expression of significant quantities of approximately 78 kDa and 104 kDa outer membrane proteins. The vaccine may be prepared using the entire cell culture or fractions thereof.