NOVEL TUMOR-INHIBITING BISINDOLE DERIVATIVES WITH CALMODULIN-LIBERATOR EFFECT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

摘要

The invention relates to novel spiro-2',4'-dioxo-oxazolidino-bisindole derivatives of formula (I), wherein: R1 means a methyl or formyl group; and R2 stands for a C1-4 alkyl, C3-4 alkenyl or halogenated C2-4 alkyl group, as well as acid addition salts thereof. Furthermore, the invention relates to the preparation of the above new compounds as well as pharmaceutical compositions containing the new compounds as active ingredients. The new compounds and compositions have a cytostatic antitumoral effect involving a new mechanism of action. In addition, these compounds show a calmodulin-liberator effect.