Unique elastase induced fibrinogen cleavage site antigens

摘要

Novel peptides associated with the amino and carboxyl termini of human leukocyte elastase cleavage sites of human fibrinogen are disclosed. The peptides are used to raise antibodies which are specific for as few as five amino acids on either side of the enzymatic cleavage site. The unique peptides are also used in novel assays for the rapid determination of in vivo and in vitro elastase cleavage products.