Process for the preparation of alkyloxazole derivatives fluorinated on a side chain and novel alkyloxazole derivatives fluorinated on a side chain

摘要

Prepn. of 4-fluoromethyl-5-phenyl-oxazolidine, -oxazoline or oxazolidin-2-one derivs. of formula (I) comprises reacting the corresp. 4-hydroxymethyl cpd. of formula (II) with an alpha , alpha -difluoroalkylamine of formula (III). The novelty is that reaction is carried out at a press. below 2 bars, in presence of an inert solvent which boils above 100 degrees C (under normal press.). X1=H, NO2, alkylthio, etc.; X2=alkyl, haloalkyl, cycloalkyl, etc.; X3=H or as X2; X4=H; or X2+X3=O or X3+X4=bond; Y1=F or Cl; Y2=F, Cl or CF3; Y3,Y4=alkyl; or Y3+Y4=4-5C (un)satd. hydrocarbon chain; alkyl moieties have 1-6C.