Latex particles of glycosylated mineral oxides, process for the preparation of such particles and use thereof as biological detecting agents of affinity chromatography agents

摘要

New prods. (I) comprise latex or inorganic oxide particles to whose surface, terminally-glycosylated chains are attached. Pref. particles are polystyrene latex or silica microspheres to which chains of formula (II) -(CH2)n-NR1-CHR4-CHR3-CO-NR2-glyc are attached at density of 0.4-50 chains/Nm2. In (II), R1 is H or 1-4C alkyl; R2 is H or a 1-14C alkyl or 7-14C aralkyl gp. opt. substd. by one or more carboxylate or sulphonate gps.; R3 and R4 are H or 1-6C alkyl; n is 1-10; and glyc is glucose, galactose, galactopyranose, glycofuranose, fructose, fructopyranose, sucrose and lactose residue.