ORAL WATER SOLUBLE PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRONE DERIVATIVE AND CALCIUM SALT

摘要

PCT No. PCT/EP94/02465 Sec. 371 Date Feb. 1, 1996 Sec. 102(e) Date Feb. 1, 1996 PCT Filed Jul. 26, 1994 PCT Pub. No. WO95/07701 PCT Pub. Date Mar. 23, 1995Oral water-soluble pharmaceutical compositions containing a therapeutically effective amount of a water-soluble and stable estrogen compound such as estropipate (piperazine estrone sulfate), and at least one water-soluble, pharmaceutically acceptable calcium salt in the presence of a suitable, pharmaceutically acceptable excipient. Compositions which include an organic acid and a calcium carbonate or bicarbonate compound which reacts with the organic acid when the composition is added to water to provide effervescence are preferred.