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USE OF AN AGENT WHICH MODULATES TYROSINE PHOSPHORYLATION FOR MODULATING THE PERMEABILITY OF A PSYCHOLOGICAL BARRIER
USE OF AN AGENT WHICH MODULATES TYROSINE PHOSPHORYLATION FOR MODULATING THE PERMEABILITY OF A PSYCHOLOGICAL BARRIER
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机译:使用可调节酪氨酸磷酸化的试剂来调节心理障碍的渗透性
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摘要
Permeability of the blood-brain barrier and other physiological barriers can be modulated by the degree of tyrosine phosphorylation of proteins. Agents which promote tyrosine protein dephosphorylation reduce the permeability of the blood-brain barrier and those which promote phosphorylation increase permeability. Increasing blood-brain barrier permeability is useful in delivering drugs having a desired effect upon the central nervous system; decreasing blood-brain barrier permeability and other physiological barrier permeability is useful in preventing undesired compounds reaching the CNS and in certain clinical conditions.
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