OXAZOLINONE DERIVATIVE HAVING INTRACELLULAR PHOSPHOLIPASE A₂INHIBITOR ACTIVITY With Intracellular Phospholipase A 2 Inhibitory Activity

摘要

The present invention relates to a compound of the general formula and a pharmaceutical composition containing the same:;Wherein a and b are each carbon atoms; combination of a and b Represents a single bond or a double bond; X is a hydrogen atom, an optionally substituted aryl group, an optionally substituted heteroaryl group or an optionally substituted aralkyl group; Y is a hydrogen atom, an optionally substituted aryl group, an optionally substituted aralkyl group or a carboxyl group or a related functional group thereof; Z is a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aralkyl group, an optionally substituted arylalkenyl group, an optionally substituted heteroarylalkyl, optionally substituted Heteroarylalkenyl groups, optionally substituted aryloxyalkyl groups, optionally substituted aralkyloxyalkyl groups, optionally substituted arylcarbonylalkyl groups, optionally substituted arylsulfonyl alkyl groups, optionally substituted heteroarylsulfonylalkyl groups , Optionally substituted aminoalkyl group, optionally substituted aralkyloxycarbonyl group, optionally substituted arylcarbonyl group, optionally substituted alkylsulfonyl group, optionally substituted arylsulfonyl group or optionally substituted heteroarylsulfonyl group Provided that X, Y and Z are not simultaneously hydrogen atoms.;The compound of the present invention has intracellular posipolipase A ₂ inhibitory activity.