Therapeutic anti-HIV oligonucleotides and pharmaceutical formulations thereof (THERAPEUTIC ANTI-HIV OLIGONUCLEOTIDE AND PHARMACEUTICAL)

摘要

In the present invention, the conserved RTI ID = 0.0 Oligonucleotides having a nucleotide sequence that hybridizes to at least nucleotides 324 to 348 of the region are disclosed. The oligonucleotide has about 25 to 30 nucleotides linked by at least one non-phosphodiester internucleotide linkage that causes the oligonucleotide to be resistant to nuclease digestion. Also disclosed herein are therapeutic formulations containing such oligonucleotides and methods of inhibiting HIV-1 proliferation and methods of treating HIV-1 infection in mammals.