Oral solid preparations of novel pyridonecarboxylic acid compounds and methods for their preparation

摘要

1. Technical field to which the invention described in the claims belongs;Chemical chemistry;2. Technical Problems to be Solved by the Invention;The invention relating to the preparation of a novel pyridonecarboxylic acid compound.;3. The point of the solution of the invention;The present invention relates to a preparation of a novel pyridonecarboxylic acid compound which is an antimicrobial active compound represented by the following general formula (I), a process for producing the same, and capsules and tablets containing the same.;Wherein R_OneRepresents a lower alkyl group, a lower alkyl group substituted by halogen, a lower alkenyl group, a cycloalkyl group or a substituted or unsubstituted phenyl group; R₂Represents hydrogen, a lower alkyl group or an amino group; Y represents nitrogen or C-X group (wherein X represents hydrogen, halogen or alkoxy group); R represents hydrogen or a lower alkyl group; In the structure of Z, R₃And R₄Is hydrogen, R₅And R₆Is an amino group which is unsubstituted or substituted with a hydroxyl group, a lower alkoxy or a lower alkyl group.;Especially 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-([ , 5 , 6 The HCl salt of 6-amino-1-methyl-3-azabicyclo [3.2.0] heptan-3-yl)-1,8-naphthyridine-3-carboxylic acid is a potent antimicrobial compound.;4. Important Uses of the Invention;An oral solid preparation of a pyridonecarboxylic acid compound