Genetic engineering method of Ub-A545, the fusion protein of the epitope of Helicobacter pylori

摘要

The present invention relates to a fusion protein, which is useful for shearing duodenal ulcers, in which a part of a toxin-related protein that is a specific antigen of Helicobacter pylori is linked to ubiquitin, and the N terminal 545 amino acids of the toxin-related protein. The fusion protein Ub-A545, which comprises a constituent protein linked to ubiquitin, a gene encoding the fusion protein, a vector including the gene, a microorganism transformed by the vector, and the fusion protein expressed in the microorganism. Provided is a method for preparing Ub-A545 using microorganisms.