An erythromycin derivative-producing microorganism, and an erythromycin derivative-producing microorganism and a recombinant DNA plasmid for use in the preparation of such microorganism,

摘要

Disclosed herein are genetically modified microorganisms which produce 6-deoxyerythromycin and 6-deoxy-15-norerythromycin of the general formula (I) and pharmaceutically acceptable salts and esters thereof and the preparation of such microorganisms Lt; RTI ID = 0.0 plasmid / RTI ;Wherein R ₁ is selected from OH and H, and R ₂ and R ₃ are independently selected from H and CH ₃ .