6-HETEROCYCLIC 4-AMINO-1,3,4,5-TETRAHYDROBENZCDINDOLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT AND A METHOD OF THEIR SYNTHESIS

摘要

FIELD: heterocyclic compounds. SUBSTANCE: products: 6-heterocyclic 4-amino-1,3,4,5-tetrahydro[cd] indoles as racemate or stereoisomers of the formula where R¹ - C₁-C₄-alkyl or cyclopropylmethyl; R² - C₁-C₄-alkyl, cyclopropylmethyl; R³ - hydrogen or amino-protective group; Het - aromatic five- or six-member heterocyclic ring with 1-3 similar or different atoms - sulfur, oxygen and nitrogen. Condition: 6-member ring can contain only carbon and nitrogen and 5-member ring contains onle one oxygen or sulfur atom, not more, but not both - oxygen and sulfur, or their pharmaceutically acceptable salts. Reaction conditions: compounds of the formula were synthesized from compounds of the formula or by reaction of compound of the formula with hydrazine, or by amino-protective group removal from the compound of the formula . Synthesized compounds were used as agents modifying serotonin function. ???EFFECT: improved method of synthesis. 11 cl, 2 tbl