DIHYDROCHLORIDE OF 4,5-DI-(3amp;prime;,4amp;prime;-DIMETHOXYPHENYL)-2-MORPHOLINOETHYLTHIO IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA

摘要

FIELD: medicine, organic chemistry. SUBSTANCE: desired product is prepared by interaction of thiocynate of NH₄ and dioxane. The process is carried out by boiling, it is followed by treatment with hydrobromide of 2-morpholinoethyl bromide. The latter process takes place in aqueous-alcohol medium in the presence of NaOH. Thus obtained base is converted into hydrochloride with the help of concentrated HCl. Thus prepared oil is ground with isopropanol and then desired product is separated. Its yield is 46.1 %. Melting point of desired product is 230 C, its toxicity being 932 mg/kg. EFFECT: improves quality of desired product. 1 tbl