severe plasmodium falciparum antigens protective antibodies and their use in vaccines

摘要

A nucleotide sequence of $i(P falciparum) includes a concatenation of nucleotides comprising n successive repetitions of identical or different nucleotide fragments of 18 base pairs (bp) which code for identical or different peptides, 6 amino acids having basic pattern Asp b Asn His Lys Ser wherein b is any amino acid, or code for a variant of said basic pattern obtained by substituting one or more amino acids provided that the antigenic and/or immunogenic properties of the resulting oligopeptide are not altered, n being sufficient for the resulting nucleotide concatenation to code for an oligopeptide which can $i(in vivo) elicit antibodies that recognize the antigen encoded by the $i(P falciparum) nucleotide sequence having the given restriction map.