Method of preparation of derivatives of stereospecific 5 - (1 - hydroxy - 2 - ethylidene urethane -) - 2,2 -, - 1,3 - dioxane - 4,6 - diones precursors of derivatives of acids tetramic chiral.

摘要

The invention relates to a process for the preparation of derivatives of 5 - (1 - hydroxy - 2 - ethylidene urethane -) - 2,2 -, - 1,3 - dioxane - 4,6 - diones precursors of acid derivatives, chiral tetramic. & br / according to this process, is reacted with a carboxy anhydride n - - - - of amino acid, n - urethane protected with the acid of meldrum in an inert organic solvent medium in the presence of a tertiary amine. & br / this process makes it possible to keep the chirality of the starting compound and in particular to simplify the synthesis of 4 - amino - 3 - hydroxy acids and derivatives thereof by the channel of the acids tetramic.