THIAZINE OR THIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF NO-SYNTHETASE

摘要

The subject of the invention is thiazine or thiazepine derivatives of the following general formula (I) and their pharmaceutically acceptable salts BR/ (CF DRAWING IN BOPI) BR/ in which R ** 1 is a hydrogen atom, a substituted or unsubstituted alkyl group, a cycloalkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or an aralkyl group substituted or unsubstituted; R ** 2, R ** 3, R ** 4 and R ** 5, which may be the same or different, are each a hydrogen atom, a substituted or unsubstituted alkyl group; or R ** 1 taken together with R ** 2 or R ** 3 may represent BR/ - (CH2) n - BR/ where n is an integer of 1 to 6; BR/ A is an oxygen atom, a sulfur atom or an NH group; m is 0 or 1; and BR/ p is 0 or 1. BR/ These compounds have NO-synthetase inhibitory activity and can be used in the treatment of conditions related to excessive production of nitric oxide in vivo . / P