Synthesis of furanosyl compounds useful as intermediates in preparation of nucleoside analogues

摘要

Compounds of formulae ##STR1## wherein X is O;P PR.sup. 1 is OH, phosphate, diphosphate, triphosphate or (CH.sub.2). sub.n --O--CH. sub.2 --O--P(O)(OH).sub.2 wherein n is 0-2;P PR.sup.2 is H and R.sup.3 is CH.sub.3, CH.sub.2 OH, CH.sub.2 --O-- CH.sub.3, CH.sub. 2 SH, CH.sub.2 F or CH.sub.2 N.sub.3 ; orP PR3 is H and R. sup.2 is CH.sub.3, CH.sub.2 OH, CH.sub.2 --O--CH.sub. 3, CH.sub.2 SH, CH. sub.2 F or CH.sub.2 N.sub.3 ;PPand Z is Cl, Br, I, acyloxy or alkoxy;PPare synthesized from acyclic intermediates and are subsequently useful in the preparation of nucleoside analogues with antiviral activity against retroviruses such as HIV and hepatitis B.