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Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines
Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines
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机译:适于在肠道中适当部位释放药物的口服药物制剂
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摘要
The improved pharmaceutical preparation for oral administration which is adapted to release the drug at appropriate sites in the intestines comprises: a core that comprises an active ingredient and a pharmaceutically acceptable excipient, a first layer that covers the core and which comprises an enteric or water-soluble ingredient and an optional insoluble ingredient, a second layer that covers the first layer and which comprises a non-enteric ingredient that dissolves upon reacting with at least one ingredient in the core, and a third layer that covers the second layer and which comprises an enteric ingredient. This preparation is characterized in that it will not release the active ingredient until after it reaches a desired site in the intestines and that, in addition, it is capable of controlling the rate at which the active ingredient is released after it has reached the desired site. Therefore, this preparation is particularly effective in administering active ingredients having absorption specificity at specific sites in the intestines or for treating diseases at specific sites in the intestines.
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