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Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
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机译:吩噻嗪-5-ium染料加光灭活血液和血液成分中的细胞外包膜病毒
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摘要
This invention provides methods for inactivating pathogenic contaminants in whole blood, plasma, cellular blood components, or in any combination thereof, by adding a phenthiazin-5-ium dye(s) thereto and irradiating said dye-containing composition for an effective length of time with light of wavelengths from 560 to 800 nm or red light, of an effective intensity, whereby the irradiation in conjunction with the dye(s) inactivate substantially all pathogenic contaminants contained therein. The methods of this invention inactivate pathogenic contaminants, such as viruses, bacteria and parasites, without substantially altering the whole blood, plasma, cellular blood components, or combinations thereof, such that they are suitable for transfusion.
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