DNA sequence encoding the novel proteins and binds to the retinoblastoma protein

摘要

(57) [Abstract] Retinoblastoma protein (Rb), which is a product of the retinoblastoma gene, contains mutations in retinoblastoma cells were found. P46 and p48 nuclear protein of two that bind to Rb is isolated, gene has been cloned. These proteins bind to Rb competitively with SV40 T antigen. The p48, suppressing the heat shock sensitivity Ras mutation in yeast, is involved as a modulator of the retinoblastoma suppressor function of Rb is illustrated.