NONIONIC PARAMAGNETIC ION COMPLEX AND COMPLEXING AGENT FOR PRODUCING THE COMPLEX

摘要

PROBLEM TO BE SOLVED: To obtain the subject new complex consisting of a complex of a complexing agent such as a derivative of ethylenediamine tetraacetic acid or diethylenetriamine pentaacetic acid with paramagnetic ion, soluble, free from toxicity, stable and useful as an NMR contrast medium, etc. ;SOLUTION: A new nonionic paramagnetic ion complex of formula I {R¹ is O, a group of NR²R³ [R² is a group of the formula (CH₂CH₂O)_nR⁴ (n=1-10; R⁴ is H, a 1-8C alkyl, allyl); R³ is H, R² a 1-8C alkyl, OH, a 1-8C alkoxy, etc.]; A is a group of the formula CH₂CH₂ or formula II; M⁺Z is a paramagnetic ion of an element having an atomic number of 21-29, 42-44 or 58-70; to ionic number Z is +2 or +3} [e.g. {N,N"-bis[N-(2-methoxyethyl)- carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto}gadolinium (III)]. The complex is useful as an MNR contrast medium, etc. The complex is obtained by heating a mixture of bis(2-methoxyethylamide of a complexing agent having formula III with gadolinium oxide.;COPYRIGHT: (C)1997,JPO