AGENT FOR PREVENTION AND TREATMENT OF HYPERCOAGULATION OR HYPOFIBRINOLYTIC STATE AND ITS ANALOGOUS DISEASE

摘要

PROBLEM TO BE SOLVED: To obtain an agent for the prevention and treatment of hypercoagulation or hypofibrinolytic state, prevention and treatment of disseminated intravascular coagulation syndrome, prevention and treatment for organ failure and prevention and treatment of edema. ;SOLUTION: The agent contains a prourokinase having a single-stranded peptide bond structure and having a molecular weight of about 40,000-55,000 or its derivative as an active component. Prourokinase has actions to increase the thrombolytic rate and reduce the accumulation of water in the organ (edema) and is free from significant influence on a blood coagulation fibrinolytic parameter and, accordingly, it is extremely useful for the prevention and treatment of hypercoagulation or hypofibrinolytic state. It is useful also for the prevention, etc., of disseminated intravascular coagulation syndrome, organ failure and edema caused by hypercoagulation or hypofibrinolytic state. It is administered by introarterial infusion, intravenous injection, continuous intravenous infusion, local administration, etc., for 1-10 days at a daily dose of about 1,500-2,000U for adult.;COPYRIGHT: (C)1997,JPO