BIS QUATERNARY AMMONIUM SALT COMPOUND HAVING ANTIMICROBIAL ACTIVITY AND ITS PRODUCTION

摘要

PROBLEM TO BE SOLVED: To obtain a new compound represented by a specific formula, expressing an extremely excellent antimicrobial effect and an extremely wide antimicrobial spectrum, high in safety, and useful as an antimicrobial agent. ;SOLUTION: This compound is expressed by formula I (Z is a pyridine ring; R₁, R₂ are each H, a 1-6C alkyl; R₃ is a 3-18C alkylene, a 3-18C alkenylene; R₄ is a 6-18C alkyl bound to the ring nitrogen atom of Z; X is an anion), e.g. N,N'-hexamethylene bis(4-carbamoyl-1-dodecylpyridinium bromide). The compound is preferably obtained by reacting an alkylene biscarbamoylpyridine compound of formula II with a compound of the formula: R₄X in an organic solvent such as N,N-dimethylformamide in approximately 10-100MPa at approximately 50-100°C for 10-12hr, etc.;COPYRIGHT: (C)1997,JPO