首页> 外国专利> 2- (3-phenylpropyl) hydrazine, intermediate, process for producing the same, and therapeutic agent for personality disorder comprising the same

2- (3-phenylpropyl) hydrazine, intermediate, process for producing the same, and therapeutic agent for personality disorder comprising the same

机译:2-(3-苯丙基)肼,中间体,其制备方法以及包括该中间体的人格障碍治疗剂

摘要

The present invention relates to 2-[3-phenyl-3-(phenoxy)propyl]hydrazines of formula I CHEM wherein R is hydrogen or loweralkyl; R1 is hydrogen, loweralkyl, arylloweralkyl, a group of the formula CHEM wherein R2 is loweralkyl, or a group of the formula CHEM wherein R3 is hydrogen, loweralkyl, aryl, or arylloweralkyl; X and Y are hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl; m and n are independently 1 or 2; the optical isomers thereof; or the pharmaceutically acceptable acid addition salts thereof, which are useful for treating personality disorders such as obsessive compulsive disorders. This invention relates further to intermediates in and a process for the preparation of the compounds of formula I.
机译:本发明涉及式I 的2- [3-苯基-3-(苯氧基)丙基]肼,其中R是氢或低级烷基; R1是氢,低级烷基,芳基低级烷基,其中R2是低级烷基的式的基团或其中R3是氢,低级烷基,芳基或芳基低级烷基的式的基团; X和Y是氢,低级烷基,低级烷氧基,卤素或三氟甲基; m和n独立地为1或2;其旋光异构体;或其药学上可接受的酸加成盐,其可用于治疗人格障碍,例如强迫症。本发明进一步涉及式I化合物的中间体和制备方法。

著录项

  • 公开/公告号JP2580452B2

    专利类型

  • 公开/公告日1997-02-12

    原文格式PDF

  • 申请/专利权人 HEKISUTO MARION RUSERU INC;

    申请/专利号JP19920324544

  • 申请日1992-12-04

  • 分类号C07C243/18;A61K31/15;A61K31/165;A61K31/27;C07C241/02;A61K243/10;A61K243/30;A61K271/60;

  • 国家 JP

  • 入库时间 2022-08-22 03:29:51

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