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PROCESS FOR THE PREPARATION OF CIS-1-amino-2-indanol from trans-1-AMIDO-2-HALOINDAANVERBINDING, TRANS-1-AMINO-2-HALOINDAANVERBINDINGEN AND PROCESS FOR THE PREPARATION OF TRANS-1-AMIDO-2-HALOINDAANVERBINDINGEN .
PROCESS FOR THE PREPARATION OF CIS-1-amino-2-indanol from trans-1-AMIDO-2-HALOINDAANVERBINDING, TRANS-1-AMINO-2-HALOINDAANVERBINDINGEN AND PROCESS FOR THE PREPARATION OF TRANS-1-AMIDO-2-HALOINDAANVERBINDINGEN .
The invention relates to a process for the preparation of cis-1-amino-2-indanol, wherein first a trans-1-amido-2-haloindane according to formula 1, wherein X is a halogen, in particular Br, and R an alkyl alkenyl or aryl group, preferably methyl, is cyclized under acidic conditions and optionally then subjected to a, preferably acidic, hydrolysis. The invention also relates to trans-1-amido-2-haloindane compounds of the formula 1, in particular trans-1-acetamido-2-bromoindane, and processes for the preparation of a trans-1-amido-2-haloindane of the formula 1 wherein the corresponding trans-2-halo-1-indanol is contacted with a nitrile of formula RC = N or in which indene is contacted with a donor of a positive halogen and a nitrile of formula RC = N, both in the presence of an acid, for example sulfuric acid. A particularly attractive process for the preparation of cis-1-amino-2-indanol is to obtain indanol without intermediate isolation of the intermediately formed products. Cis-1-amino-2-indanol, in particular optical active cis- (2R, 1S ..
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