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NEW MEDICAMENTOUS FORMS OF CYCLOSPORIN FOR ORAL APPLICATION OF NO COMPLEX COMPOSITION AND HIGH BIOACTIVITY AND METHOD FOR THEIR PREPARATION
NEW MEDICAMENTOUS FORMS OF CYCLOSPORIN FOR ORAL APPLICATION OF NO COMPLEX COMPOSITION AND HIGH BIOACTIVITY AND METHOD FOR THEIR PREPARATION
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机译:无复杂成分和高生物活性的环孢菌素口服新药及其制备方法
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摘要
The medicamentous forms of cyclosporin with a composition which is not complex and having high bioactivity in oral application contains 0.5-2 wt.pts of one or more cyclosporins, preferably cyclosporin A and/or G, 6-9 wt.pts of one or more polyethyleneglycol esters of saturated C10-C22 hydroxyfatty acids, in particular SOLUTOLR HS 15, and 1-3 wt.pts of one or more monovalent of polyvalent alcohols, preferably ethanol and propyleneglycol. The medicamentous form is originally produced by the dissolution of the amorphous cyclosporin in ethanol and the addition with accompanying agitation of propyleneglycol and SOLUTOLR until transparent viscous solution is produced which is packed in capsules or is used in the form of a solution for oral application.
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