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Compounds use and preparation process of the same pharmaceutical compositions use of same and process of treatment of attacks neurological disorders and / or conditions in which there is neurological damage in animals including humans
Compounds use and preparation process of the same pharmaceutical compositions use of same and process of treatment of attacks neurological disorders and / or conditions in which there is neurological damage in animals including humans
PCT No. PCT/EP94/03364 Sec. 371 Date Jun. 25, 1996 Sec. 102(e) Date Jun. 25, 1996 PCT Filed Oct. 12, 1994 PCT Pub. No. WO95/10521 PCT Pub. Date Apr. 20, 1995Compounds of formula (I) which includes pharmaceutically acceptable salts thereof and stereoisomers thereof: IMAGE (I) wherein: R1 represents H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6 alkyl, C1-6 alkoxy or C1-6 alkanoyl; R2 and R3 independently represent H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C1-6 alkyl, C1-6 alkoxy or C1-6 alkanoyl, C1-6 alkylthio, C1-6 alkylsulphinyl or C1-6 alkylsulphonyl; R4 and R5 combined together with the carbon atom to which they are attached represent C3-6 cycloalkylidene (each alkyl or cycloalkylidene being optionally substituted with one or more of halo, cyano, hydroxy, amino or C1-6 alkyl); and R6, R7 and R8 independently represent H, halo, hydroxy, mercapto, cyano or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino; and any nitrogen atom being optionally substituted with one or more C1-6 alkyl): C1-6 alkyl, C1-6 alkoxy or C1-6 alkanoyl, C1-6 alkylthio, C1-6 alkylsulphinyl, etc; have utility in the treatment and/or prophylaxis or seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, head injuries and haemorrhage.
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