HETEROCYCLIC AROMATIC OXAZOLE COMPOUNDS, THEIR OXIME, KETONE, KETONEMETHYLENE, ESTER AND AMIDE COMPOUNDS, PHARMACEUTICAL PREPARATIONS, CYCLOOXYGENASE INHIBITORS AND ANTIPHLOGISTIC AGENTS IN WHICH SAID OXAZOLE COMPOUNDS ARE COMPRISED

摘要

A heterocyclic aromatic oxazole compound of the formula (I) CHEM wherein Z is an oxygen atom; one of R and R1 is a group of the formula CHEM wherein R3 is lower alkyl, amino or lower alkylamino, and R4, R5, R6 and R7 are the same or different and each is hydrogen atom, halogen atom, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy or amino, provided that at least one of R4, R5, R6 and R7 is not hydrogen atom, and the other is an optionally substituted cycloalkyl, an optionally substituted heterocyclic group or an optionally substituted aryl; and R2 is a lower alkyl or a halogenated lower alkyl, and a pharmaceutically acceptable salt thereof. The heterocyclic aromatic oxazole compound and pharmaceutically acceptable salts thereof have antipyretic action, analgesic action, anti-inflammatory action, and particularly, selective inhibitory action on cyclooxygenase-2 (COX-2), and are expected to be useful as anti-inflammatory agents with less side-effects such as digestive tract disorders.