£2R,3R(2R',3R'),6R,7S,8S,9R,10R-3-(2',3'-DIHYDROXYPENT-2'-YL) -2,6,8,10,12-PENTAMETHYL-4,13-DIOXABICYCLO £8.2.1TRIDEC-12-EN-5-ONE DERIVATIVE, PROCESS OF ITS PREPARATION AND PHARMACEUTICAL PREPARATION IN WHICH SAID DERIVATIVE IS COMPRISED

摘要

The derivatives | 2R, 3R (2R ', 3R), 6R, 7S, 8S, 9R, 10R | -3- (2', 3'-dihydroxypent-2'-yl) -2,6,8,10, 12-pentamethyl4,13-dioxabicyclo [8.2.1] tridec-12-en-5-one of the formula (I) wherein R 1 is methyl or hydrogen and their physiologically tolerable acid addition salts are stable . The process for the preparation of these derivatives is that in the derivative, R, 3R (2R ', 3R'), 6R, 7S, 8S, 9R, 10R | -3- (2 ', 3'-dihydroxypent-22'-yl) Of the formula (II) in which R.sup.1 is as defined above, -2,6,8,10,12-pentamethyl-4,13-dioxabicyclo [8.2.1] tridec-12-en5-one; introducing an isopropyl radical, and, if necessary, introducing a methyl radical R @ 1 into the obtained compound of formula (I) in which R @ 2 is hydrogen, or In which R.sup.1 is methyl, the methyl radical R.sup.1 is cleaved and, if desired, the free compounds of the formula I are converted into their stable acid addition salts, or the addition salts are converted into free compounds of formula (I)