Cylopentan-pyridyloxazolidininones containing heteroatom, their method of manufacture, their use in the manufacture of medicinal products and medicinal products containing these compounds

摘要

Oxazolidinone derivatives of formula (I) and their salts are new. A = a group of formula (a) or (b); E, G, L, M = N or CR4, provided that at least one is N; R4 = H, Me or halo; R2, R5 = H, 3-8C cycloalkyl, 3-8C cycloalkylcarbonyl or 1-8C alkyl (optionally substituted by OH, halo, 1-6C alkoxy, 1-6C alkoxycarbonyl, 1-6C alkylthio or NR6R7); R6, R7 = H, cycloalkyl, Ph or 1-4C alkyl; R3 = 1-8C alkyl or 1-8C thioalkyl; D = 0, S or NR5; T = O or S; R1 = azido, OH, OR8, OSO2R9 or NR10R11; R8 = 1-8C acyl or a hydroxy protecting group; R9 = 1-4C alkyl or Ph (optionally substituted by 1-4C alkyl); R10, R11 = 3-6C cycloalkyl, H, Ph, 1-8C alkyl, 1-8C alkoxy, amino protecting group, COR12, CSR12, P(O)(OR13)(OR14) or SO2R15; R12 = H, 3-6C cycloalkyl, CF3, 1-8C alkoxy, Ph, benzyloxy, H, 1-8C alkyl (optionally substituted by CN, halo or CF3), 1-6C thioalkyl, 1-6C acyl or NR16R17; R16, R17 = H, Ph, 1-6C alkyl or a five-membered aromatic heterocycle with 1-4 heteroatoms chosen from S, N and/or O); R13, R14 = H or 1-4C alkyl; R15 = 1-4C alkyl or Ph.