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CELL-SPECIFIC ENZYME-CONJUGATES FOR THE RELEASE OF TOXIC CYANIDE FROM CYANOGENIC PRODRUGS AT TARGET CELLS
CELL-SPECIFIC ENZYME-CONJUGATES FOR THE RELEASE OF TOXIC CYANIDE FROM CYANOGENIC PRODRUGS AT TARGET CELLS
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机译:细胞特异性酶结合物从靶细胞的氰基产物释放有毒的氰化物
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摘要
A conjugate compound comprises a cell-specific portion, such as an antibody specific to tumour cell antigens, and an enzymatically active portion which will cleave a cyanogenic compound to release cyanide. Enzymes such as beta -glucosidases are suitable. The cyanogenic compound, e.g. amigdalin or some other plant-derived saccharide, is administered after the conjugate. Intravesical (intra-bladder) administration is preferred (for bladder cancers) and forms a further aspect of the invention, whether the compound is cyanide-liberating (as above) or suitable for therapy or imaging in any other way.
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