INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE

摘要

A method for inhibiting growth of Pneumocystis carinii in a mammalian host, which comprises administering to the host an amount of a 1-phenyl-s-triazine effective to inhibit growth of P. carinii. Preferred compounds have formula (I), wherein X, Y, and Z are independently selected from preferred organic substituents described in the specification; R1 is lower alkyl; and R2 is hydrogen or methyl; as well as compounds formed by reaction of an organic or inorganic acid with a triazine of this formula to form an amide or acid addition salt. Administration of precursors which form the triazine in vivo is also within the scope of the invention.