Process for the preparation of 3-alkylated indoles intermediates useful in this process and the use of (2-nitrophenyl) acetaldehyde in the preparation of 4-5-(N-4,4,4-trifluoro-2-methylbutyl-carbamoyl)-1-methylindol-3- ylmethyl-3methoxy-N-o-tolylsulphonyl-benzamide

摘要

A process for the preparation of a 3-alkylated indole, which comprises:- a) reacting a N-(2-nitrostyryl) enamine with an alkylating agent to afford an imine salt, b) optionally reacting the imine salt with water to afford a (2-nitrophenyl)acetaldehyde, and c) reacting the imine salt or the (2-nitrophenyl)acetaldehyde with a reducing agent capable of selectively reducing the nitro group, to afford the desired 3-alkylated indole. a