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AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING
AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING
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机译:叠氮烷基衍生物及其在制备99mTc成像复合物中的用途
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摘要
Compounds of the formula T-R-Y wherein T is a targeting group derived from a molecule T( which has an affinity to a specific body tissue said targeting group essentially retaining the specific affinity of said molecule; R is a branched or straight alkylene chain having 1 to 6 carbon atoms; and Y is axido -N3. They are used in a method for the preparation a 99mTc complex of a compound of the above formula useful for in vivo imaging, comprising: (a) preparing an aqueous solution of the above compound; (b) preparing a reaction mixture by adding an acid and a solution of pertechnetate of 99mTc (a salt solution of 99mTcO4s); (c) providing appropriate reaction conditions whereby said complex of 99mTc with the said compound is formed.
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