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Process for preparing a crystalline cefepime dihydrochloride as well as the crystalline dihydrochloride and mixtures containing it.
Process for preparing a crystalline cefepime dihydrochloride as well as the crystalline dihydrochloride and mixtures containing it.
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机译:制备结晶的头孢吡肟二盐酸盐以及结晶的二盐酸盐及其混合物的方法。
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摘要
Temp. stable crystalline salts of alpha-(2-aminothiazol-4-yl) alpha-(Z)-methoxyiminoacetamido) -3 -(1-methyl-1-pyrrolidinio) methyl)-3-cephem-4-carboxylate (I) are claimed, selected from sulphuric, di-nitric, monohydrochloric and di-hydrochloric acid addn. salts and orthophosphoric acid addn. salts contg. 1.5-2 molar equivalents of H3PO4, or solvates of tehse. The salt may be mixed with a base e.g. L(+) lysine or L(+) arginine.
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