METHOD AND DEVICE FOR COMBINED ENRICHMENT, PROCESSING AND EMBEDDING OF CYTOLOGICAL SPECIMENS ACCORDING TO HISTOLOGICAL PRINCIPLES

摘要

PCT No. PCT/FI90/00197 Sec. 371 Date Apr. 30, 1992 Sec. 102(e) Date Apr. 30, 1992 PCT Filed Aug. 15, 1990 PCT Pub. No. WO91/03480 PCT Pub. Date Mar. 21, 1991.The present invention concerns a novel process for the preparation of methylenebisphosphonic acids of the formula I IMAGE (I) wherein Q1 and Q2 are independently hydrogen or halogen, by hydrolyzing the corresponding methylenebisphosphonic acid tetraester of the formula IMAGE (II) wherein R has the meaning of a straight or branched alkyl group containing 1 to 4 carbon atoms, and Q1 and Q2 have the same meaning as above.