6-PHENYL-, PYRIDYL-, FURANYL- AND THIENYL- SUBSTITUTED 5,6-DIHYDROIMIDAZO (2,1-B) THIAZOLE DERIVATIVES; PREPARATORY PROCESSES, INTERMEDIATES THEREFOR AND PHARMACEUTICAL COMPOSITIONS

摘要

Novel 6-aryl-5,6-dihydroimidazo[2,1-b]thiazole derivatives of formula CHEM wherein Ar is phenyl optionally substituted with halo, hydroxy, C1-6alkyloxy, mercapto, C1-6alkylthio, C1-6alkyl, nitro, amino, mono- and di(C1-6alkyl)amino, C1-6alkylcarbonylamino, arylcarbonylamino, C1-6alkylsulfonylamino, trifluoromethyl, cyano, aminocarbonyl, mono- and di(C1-6alkyl)aminocarbonyl, hydroxycarbonyl, C1-6alkyloxycarbonyl, carboxaldehyde or hydroxymethyl; pyridinyl; thienyl; furanyl or furanyl substituted with either C1-6alkyl or halo; R1 and R2 are C1-20alkyl, (C3-7cycloalkyl)C1-6alkyl, C3-7cycloalkyl, aryl or (aryl)C1-6alkyl; one of R1 and R2 may by hydrogen; or R1 and R2 taken together may form a C3-6alkanediyl radical; the acid addition salts and stereochemically isomeric forms thereof, said compounds having immunostimulating properties. Pharmaceutical compositions containing such compounds as active ingredient. Processes of preparing said novel compounds and pharmaceutical compositions.