The Intravenous Iron in Maintenance of anaemia is handled

摘要

The novel farnesyl transferase inhibitors of logical formula (I), their preparation and pharmaceutical compositions include identical. In general formula(I)In,R1 is Y-S-A1-(Y is a hydrogen atom,Amino acid residue,One fatty acid residue,One alkyl or alkoxycarbonyl radical or a R4-S free radical,Wherein R4 is an alkyl,Comprising by general formula(II)A phenyl group or the 1-4 carbon atoms that optionally replace of a free radical,Wherein A1,X1 ,Y1 ,R'1 ,R2 ,R'2 and R are defined as follows: A1 is monobasic C with an amino or alkylamino that an alkylene radical optionally includes the α of 1-4 carbon atoms in a packet(X1)(Y1),Dialkylamino,Alkanylamino or alkoxycarbonylamino free radicals),X1 and Y1 is individually a hydrogen atom or form together with one C of carbon atom that wherein they are connected=O-shaped,R'1 is hydrogene or methyl,R2 is an alkyl,Alkenyl or alkynyl group,Comprising 1-6 carbon atoms by hydroxyl,Alkoxy,Sulfydryl,Alkylthio group,What alkylsulfinyl or alkyl sulphonyl optionally replaced,Condition when R2 is the alkyl replaced by a hydroxy radical,R2 can form the lactone with the carboxyl free radical in α. R'2 is hydrogen or methyl, and R is that a hydrogen atom or an alkyl selectively replaced or the phenyl radical of an optional substitution, whith free radicals (a) are in the restrictive clause of the position 5 or 6 of naphthalene ring. These new products have anti-cancer properties.