DETECTION OF DS DNA BY CONTACTING THE DNA WITH AN OLIGOMER HAVING AT LEAST SEVEN NUCLEOSIDYL UNITS WHICH IS COMPLEMENTARY ENOUGH TO FORM A TRIPLE HELIX; PREVENTION OF DNA EXPRESSION

摘要

A specific segment of double stranded DNA may be detected or recognized by formation of a triple helix structure using an oligomer comprised of nucleosidyl units linked by internucleosidyl phosphorus linkages. Function or expression of double stranded DNA segments may be prevented by triple helix formation. Novel oligomers comprising modified nucleosidyl units are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.