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COATED MICROPARTICLES STABILISED BY A COATING OF AT LEAST ONE FILM-FORMING AGENT AND PORE-FORMING AGENT, THE PARTICLES BEING OF 50-1000 UM IN SIZE
COATED MICROPARTICLES STABILISED BY A COATING OF AT LEAST ONE FILM-FORMING AGENT AND PORE-FORMING AGENT, THE PARTICLES BEING OF 50-1000 UM IN SIZE
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机译:通过至少涂覆一层成膜剂和成孔剂来稳定涂层的微粒,粒径为50-1000 UM
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摘要
Such stabilised active agents make it possible to obtain dry and stable pharmaceutical, dietetic, food or cosmetic compositions in which the properties of the said active agents are neither modified nor altered. Such powdery active agents are stabilised by coating with a coating composition comprising: - at least one film-forming agent, in proportions of between 2 and 25% by weight of the final mass, selected from polyvinylpyrrolidones (povidone), polyvinyl alcohols, vinylpyrrolidone-vinyl acetate copolymer, vinylpyrrolidone-polyvinyl alcohol, cellulose derivatives such as cellulose acetate, cellulose acetate phthalate, cellulose butyrate, ethyl cellulose, methyl cellulose, acrylic and methacrylic polymers and copolymers and vegetable, animal or synthetic waxes, and - at least one (pre-forming) agent, in proportions of between 0 and 5%, preferably between 0.5 and 5%, by weight of the final mass, selected from microcrystalline lactose, low-molecular weight polyethylene glycols, calcium carbonate, calcium phosphate, sucrose, sodium chloride and potassium chloride. The powdery stabilised active agent, in the form of microparticles, has a particle size of between 50 and 1000 mu m, preferably between 200 and 500 mu m.
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