HUMANISED ANTIBODY; VARIABLE LIGHT CHAIN AND HEAVY CHAIN SEQUENCES DERIVED FROM BOVINE ANTI-RSV F PROTEIN MONOCLONAL ANTIBODIES, AND CDR PEPTIDES THEREFROM

摘要

The present invention provides variable light chain and variable heavy chain sequences derived from bovine anti-RSV F protein monoclonal antibodies (mAbs), B4 and B13/B14, and CDR peptides therefrom, which may be employed in the design of fusion proteins (including altered antibodies) which are charaterized by the antigen binding specificity of these mAbs. Also described is a humanized antibody containing bovine variable chain sequences. Methods for producing and using these compositions, including pharmaceutical compositions are disclosed.