MANUFACTURE OF DRUG-CONTAINING PARTICLES FROM A MIXTURE OF PARTICULATE DRUG AND A PARTICULATE HYDROPHOBIC AND/OR HYDROPHILIC FUSIBLE CARRIER OR DILUENT IN A HIGH SPEED MIXER SUCH THAT THE CARRIER/DILUENT MELTS AND BREAKING UP THE AGGLOMERATES THUS FORMED; SUSTAINED RELEASE FORMS

摘要

A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.