MILK-DERIVED BASIC PROTEIN COMPOSITION FOR STIMULATING OSTEOBLASTIC PROLIFERATION, STRENGTHENING BONE AND INHIBITING BONE RESORPTION

摘要

The present invention can provide a basic protein and/or a basic peptide composition which can be orally taken and has action of simulating osteoblastic proliferation, strengthening bone and inhibiting bone resorption. Said basic protein has the following properties: (1) the molecular weight distribution thereof is 2,000-24,000; (2) the isoelectric point thereof is 7.5-11; and (3) it comprises more than 10% of basic amino acids as composing amino acids. Said composition can be obtained by the following steps: After milk or raw material derived from milk is loaded on a cation exchange resin column, a fraction obtained by eluting with an eluent of 0.1-1.0M salt concentration is precipitated by heating over 75 DEG C, (ii) by adding alcohol so that the final concentration thereof will be 10-50% or (iii) by adding salts so that the final concentration thereof will be more than 0.2M; and the supernatent thereof can be recovered. IMAGE