NOVEL CRYSTAL FORM OF ANHYDROUS 7-((1ALPHA, 5ALPHA,6ALPHA)-6-AMINO-3-AZABICYCLO (3.1.0.) HEX-3-IL) -6-FLUORO-1- (2,4 DIFLUOROPHENYL) -1,4-DIHYDRO-4-OXO-1,8 NAPHTHYRIDINE -3-CARBOXYLIC ACIDS, METHANESULFONIC ACID SALT

摘要

New crystal form, (I'), of 7-([1~a, 5~a, 6~a]-6-amino-3-azabicyclo [3.1.0] hex-3-yl)-6- fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acid, methanesulphonic acid salt (I), is characterised by the following major peaks in its X-ray powder diffraction pattern: Peak number; 2~h( deg )Cu; d space: (1; 4.5; 19.5); (2; 7.7; 11.5); (3; 9.1; 9.7); (4; 13.6; 6.5); (5; 15.0; 5.9); (6; 18.2; 4.9); (7; 18.6; 4.8); (8; 22.8; 3.9).