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3.9 - disubstituierte - spiro (5.5) undecane with cardiovasculaire effect, methods for their manufacture and pharmaceutical preparations containing them
3.9 - disubstituierte - spiro (5.5) undecane with cardiovasculaire effect, methods for their manufacture and pharmaceutical preparations containing them
Spiro(5,5)undecane derivs. of formula (I) and their salts and isomers are new: In (I), R = H, or 2-6C alkyl or alkenyl opt. substd. by a quat. ammonium gp. or one or more OH, 1-6C alkoxy, COOH, NR4R5, NHC(NH)NHR6 or C(NH)NR7R8 gps; R4 and R5 = H, 1-6C alkyl, benzyl or phenyl, or NR4R5 is an opt. substd. satd. or unsatd. 5- or 6-membered monoheterocyclic ring opt. contg. another heteroatom (O, S or N); R6-R8 = H or 1-4C alkyl; n = 0-4; Y = O or S; A = CHB, C(OR1)B or C=N-NR2-CZ-NHR3; R1 = H or Me, B = 1-6C alkyl or 2-6C alkenyl substd. by (a) OH, NH2, oxo or = N-NR2-CZ-NHR3; or (b) a satd. or unsatd. 5- or 6-membered monoheterocyclic ring contg. one or more heteroatoms (O, S or N), opt. mono- or polysubstd. by OH, oxo, NH2 or 1-6C alkyl; R2 and R3 = H, 1-6C alkyl, benzyl or phenyl, or R2 + R3 forms an opt. substd. satd. or unsatd. 5- or 6-membered monoheterocyclic ring; Z = O, S or NR9; R9 = H, 1-4C alkyl or CN; or R9 + R2 or R9 + R3 forms an opt. substd. 5- or 6-membered monoheterocyclic ring.
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